Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

Isolation of C11 Cyclopentenones from Two Didemnid Species, Lissoclinum sp. and Diplosoma sp.

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A series of new C11 cyclopentenones 1-7 was isolated, together with four known Collectibles metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp.The other didemnid ascidian Diplosoma sp.contained didemnenones 1, 2 and 5, and five known metabolites 8-12.

The structures of 1-7 were elucidated by spectroscopic analyses.Cytotoxicity of the isolated compounds was evaluated against three Western Barrel saddle youth human cancer cell lines (HCT116, A431 and A549).